Recent advances of organ-on-a-chip in cancer modeling research
X Liu, Q Su, X Zhang, W Yang, J Ning, K Jia, J Xin, H Li… - Biosensors, 2022 - mdpi.com
Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …
remains one of the leading causes of death worldwide. Due to the unclear molecular …
[HTML][HTML] Tumor-on-a-chip models combined with mini-tissues or organoids for engineering tumor tissues
The integration of tumor-on-a-chip technology with mini-tissues or organoids has emerged
as a powerful approach in cancer research and drug development. This review provides an …
as a powerful approach in cancer research and drug development. This review provides an …
New strategy for promoting vascularization in tumor spheroids in a microfluidic assay
Z Wan, MA Floryan, MF Coughlin… - Advanced …, 2023 - Wiley Online Library
Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …
impact of intravascular flow on tumor progression and treatment. However, these models …
Adaptable microfluidic vessel-on-a-chip platform for investigating tumor metastatic transport in bloodstream
Cancer metastasis counts for 90% of cancer fatalities, and its development process is still a
mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well …
mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well …
Microfluidic droplet-assisted fabrication of vessel-supported tumors for preclinical drug discovery
High-fidelity in vitro tumor models are important for preclinical drug discovery processes.
Currently, the most commonly used model for in vitro drug testing remains the two …
Currently, the most commonly used model for in vitro drug testing remains the two …
Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …
components, surrounding the tumor, play a crucial role in disease development and …
Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip
A tumor microenvironment (TME) is a complex system that comprises various components,
including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth …
including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth …
On-chip recapitulation of the tumor microenvironment: A decade of progress
One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
Hierarchical vessel network-supported tumor model-on-a-chip constructed by induced spontaneous anastomosis
The vascular system in living tissues is a highly organized system that consists of vessels
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …
Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R
Tumor-associated inflammation drives cancer progression and therapy resistance, often
linked to the infiltration of monocyte-derived tumor-associated macrophages (TAMs), which …
linked to the infiltration of monocyte-derived tumor-associated macrophages (TAMs), which …