Recent advances of organ-on-a-chip in cancer modeling research

X Liu, Q Su, X Zhang, W Yang, J Ning, K Jia, J Xin, H Li… - Biosensors, 2022 - mdpi.com
Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …

[HTML][HTML] Tumor-on-a-chip models combined with mini-tissues or organoids for engineering tumor tissues

H Hwangbo, SJ Chae, W Kim, S Jo, GH Kim - Theranostics, 2024 - ncbi.nlm.nih.gov
The integration of tumor-on-a-chip technology with mini-tissues or organoids has emerged
as a powerful approach in cancer research and drug development. This review provides an …

New strategy for promoting vascularization in tumor spheroids in a microfluidic assay

Z Wan, MA Floryan, MF Coughlin… - Advanced …, 2023 - Wiley Online Library
Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …

Adaptable microfluidic vessel-on-a-chip platform for investigating tumor metastatic transport in bloodstream

Y Wu, Y Zhou, R Paul, X Qin, K Islam, Y Liu - Analytical chemistry, 2022 - ACS Publications
Cancer metastasis counts for 90% of cancer fatalities, and its development process is still a
mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well …

Microfluidic droplet-assisted fabrication of vessel-supported tumors for preclinical drug discovery

Y Wu, Y Zhao, Y Zhou, K Islam… - ACS Applied Materials & …, 2023 - ACS Publications
High-fidelity in vitro tumor models are important for preclinical drug discovery processes.
Currently, the most commonly used model for in vitro drug testing remains the two …

Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment

K Ravi, TJM Manoharan, KC Wang, B Pockaj… - Biomaterials, 2024 - Elsevier
Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …

Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip

G Lee, SJ Kim, JK Park - Lab on a Chip, 2023 - pubs.rsc.org
A tumor microenvironment (TME) is a complex system that comprises various components,
including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth …

On-chip recapitulation of the tumor microenvironment: A decade of progress

SM Giannitelli, V Peluzzi, S Raniolo, G Roscilli… - Biomaterials, 2024 - Elsevier
One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …

Hierarchical vessel network-supported tumor model-on-a-chip constructed by induced spontaneous anastomosis

Y Zhou, Y Wu, R Paul, X Qin, Y Liu - ACS applied materials & …, 2023 - ACS Publications
The vascular system in living tissues is a highly organized system that consists of vessels
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …

Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R

HT Nguyen, EL Kan, M Humayun, N Gurvich… - Biomaterials, 2025 - Elsevier
Tumor-associated inflammation drives cancer progression and therapy resistance, often
linked to the infiltration of monocyte-derived tumor-associated macrophages (TAMs), which …