CXCR3 in T cell function
JR Groom, AD Luster - Experimental cell research, 2011 - Elsevier
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
CXCR3 ligands: redundant, collaborative and antagonistic functions
JR Groom, AD Luster - Immunology and cell biology, 2011 - Wiley Online Library
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
Effect of alcohol on miR‐212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease
Y Tang, A Banan, CB Forsyth, JZ Fields… - Alcoholism: Clinical …, 2008 - Wiley Online Library
Background and Aims: Alcohol‐induced gut leakiness is a key factor in alcoholic liver
disease (ALD); it allows endotoxin to enter the circulation and initiate liver damage. Zonula …
disease (ALD); it allows endotoxin to enter the circulation and initiate liver damage. Zonula …
Chemokine receptor CXCR3: an unexpected enigma
L Liu, MK Callahan, DR Huang… - Current topics in …, 2005 - Elsevier
CXCR3, the receptor for CXCL9/MIG, CXCL10/IP‐10, and CXCL11/I‐TAC, is preferentially
expressed on activated Th1 T cells and has been predicted to play an important role in their …
expressed on activated Th1 T cells and has been predicted to play an important role in their …
CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?
Objective. Interferon (IFN)-γ inducible protein, CXCL10/IP-10, is a member of the CXC
chemokine family with pro-inflammatory and anti-angiogenic properties. This chemokine has …
chemokine family with pro-inflammatory and anti-angiogenic properties. This chemokine has …
The immunologic constant of rejection
E Wang, A Worschech, FM Marincola - Trends in immunology, 2008 - cell.com
The complexity underlying a pathologic process does not necessarily require a complex
explanation. The biology determining allograft or cancer rejection, autoimmunity or tissue …
explanation. The biology determining allograft or cancer rejection, autoimmunity or tissue …
CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis
RA Colvin, GSV Campanella, LA Manice… - Molecular and cellular …, 2006 - Taylor & Francis
CXCR3 is a G-protein-coupled seven-transmembrane domain chemokine receptor that
plays an important role in effector T-cell and NK cell trafficking. Three gamma interferon …
plays an important role in effector T-cell and NK cell trafficking. Three gamma interferon …
CXCL10 regulates liver innate immune response against ischemia and reperfusion injury
Y Zhai, XD Shen, F Gao, A Zhao, MC Freitas… - Hepatology, 2008 - journals.lww.com
We have shown that activation of toll-like receptor 4 (TLR4) and its interferon regulatory
factor 3 (IRF3)-dependent downstream signaling pathway are required for the development …
factor 3 (IRF3)-dependent downstream signaling pathway are required for the development …
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3
M Johnson, AR Li, J Liu, Z Fu, L Zhu, S Miao… - Bioorganic & Medicinal …, 2007 - Elsevier
A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized
and their affinity for the receptor evaluated. Compounds were evaluated in a 125I-IP10 …
and their affinity for the receptor evaluated. Compounds were evaluated in a 125I-IP10 …
Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice
JG Hyun, G Lee, JB Brown, GR Grimm… - Inflammatory bowel …, 2005 - academic.oup.com
Background Colitis in interleukin (IL)-10−/− mice is a CD4+ T helper 1 (TH1)-mediated
disease characterized by intermittent, transmural inflammation reminiscent of human …
disease characterized by intermittent, transmural inflammation reminiscent of human …