CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Background and Aims: Alcohol‐induced gut leakiness is a key factor in alcoholic liver
disease (ALD); it allows endotoxin to enter the circulation and initiate liver damage. Zonula …

CXCR3, the receptor for CXCL9/MIG, CXCL10/IP‐10, and CXCL11/I‐TAC, is preferentially
expressed on activated Th1 T cells and has been predicted to play an important role in their …

Objective. Interferon (IFN)-γ inducible protein, CXCL10/IP-10, is a member of the CXC
chemokine family with pro-inflammatory and anti-angiogenic properties. This chemokine has …

The complexity underlying a pathologic process does not necessarily require a complex
explanation. The biology determining allograft or cancer rejection, autoimmunity or tissue …

CXCR3 is a G-protein-coupled seven-transmembrane domain chemokine receptor that
plays an important role in effector T-cell and NK cell trafficking. Three gamma interferon …

We have shown that activation of toll-like receptor 4 (TLR4) and its interferon regulatory
factor 3 (IRF3)-dependent downstream signaling pathway are required for the development …

A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized
and their affinity for the receptor evaluated. Compounds were evaluated in a 125I-IP10 …

Background Colitis in interleukin (IL)-10−/− mice is a CD4+ T helper 1 (TH1)-mediated
disease characterized by intermittent, transmural inflammation reminiscent of human …