Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …

Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To
support this malignant phenotype, cells acquire molecular alterations that abrogate or …

Background Dissecting the regulatory relationships between genes is a critical step towards
building accurate predictive models of biological systems. A powerful approach towards this …

Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

CEP55 was initially identified as a pivotal component of abscission, the final stage of
cytokinesis, serving to regulate the physical separation of two daughter cells. Over the past …

Background Triple-negative breast cancers (TNBC) are considered the most aggressive
type of breast cancer, for which no targeted therapy exists at the moment. These tumors are …

Unbalanced chromosome content, so‐called aneuploidy, is a hallmark of cancer cells.
Changes in the copy numbers of chromosomes or large chromosomal regions significantly …

The centrosomal protein, CEP 55, is a key regulator of cytokinesis, and its overexpression is
linked to genomic instability, a hallmark of cancer. However, the mechanism by which it …

Epithelial ovarian carcinoma (EOC) patients often acquire resistance against common
chemotherapeutic drugs like paclitaxel and cisplatin. The mechanism responsible for the …

Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the
subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient …