In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal
plasma. An increasing number of studies have been published on the cellular origin …

The naïve pluripotent state has been shown in mice to lead to broad and more robust
developmental potential relative to primed mouse epiblast cells. The human naïve ES cell …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …

BACKGROUND Genomic studies have yielded important insights into the pathogenesis of
obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and …

MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded
by the genomes of most organisms. They regulate gene expression through …

MicroRNAs (miRNAs) as modulators of gene expression have been described to display
both tumor-promoting and tumor-suppressive functions. Although their role has been studied …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

Purpose: The molecular drivers that determine histology in lung cancer are largely unknown.
We investigated whether microRNA (miR) expression profiles can differentiate histologic …

Genome editing tools such as CRISPR/Cas9 enable the rapid and precise manipulation of
genomes. CRISPR-based genome editing has greatly simplified the study of gene function …