This review deals with physiological and biological mechanisms of neuropathic pain, that is,
pain induced by injury or disease of the nervous system. Animal models of neuropathic pain …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

Background Rat oligonucleotide microarrays were used to detect changes in gene
expression in the dorsal root ganglion (DRG) 3 days following sciatic nerve transection …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

Bcl-2-family proteins are central regulators of cell life and death. At least three major classes
of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain …

Cervical myelopathy is the most serious complication of cervical spondylosis and is the most
common acquired cause of spinal cord dysfunction. This disorder was originally described …

Neuronal cell death is a key feature of both normal nervous system development and
neuropathological conditions. The Bcl-2 family, via its regulation of both caspase-dependent …

Novel approaches are required in the clinical management of peripheral nerve injuries
because current surgical techniques result in deficient sensory recovery. Microsurgery alone …

Release of cytochrome c (cyt c) into cytoplasm initiates caspase-mediated apoptosis,
whereas activation of Akt kinase by phosphorylation at serine-473 prevents apoptosis in …

Subsequent to a peripheral nerve injury, there are changes in gene expression within the
dorsal root ganglia in response to the damage. This review selects factors which are well …