Developments in vaccine adjuvants

FZ Firdaus, M Skwarczynski, I Toth - Vaccine Design: Methods and …, 2022 - Springer
Vaccines, including subunit, recombinant, and conjugate vaccines, require the use of an
immunostimulator/adjuvant for maximum efficacy. Adjuvants not only enhance the strength …

Polyphosphazene immunoadjuvants: Historical perspective and recent advances

AK Andrianov, R Langer - Journal of Controlled Release, 2021 - Elsevier
The development of successful vaccines has been increasingly reliant on the use of
immunoadjuvants-additives, which can enhance and modulate immune responses to …

Polymer nanotechnology based approaches in mucosal vaccine delivery: challenges and opportunities

R Sharma, U Agrawal, N Mody, SP Vyas - Biotechnology advances, 2015 - Elsevier
Mucosal sites serve as the main portal for the entry of pathogens and thus immunization
through mucosal routes can greatly improve the immunity. Researchers are continuously …

[HTML][HTML] Polyphosphazenes as adjuvants for animal vaccines and other medical applications

DJ Chand, RB Magiri, HL Wilson… - … in bioengineering and …, 2021 - frontiersin.org
Polyphosphazenes are a class of experimental adjuvants that have shown great versatility
as vaccine adjuvants in many animal species ranging from laboratory rodents to large …

The potential of polyphosphazenes for delivery of vaccine antigens and immunotherapeutic agents

NF Eng, S Garlapati, V Gerdts, A Potter… - Current drug …, 2010 - ingentaconnect.com
Polyphosphazene polyelectrolytes are synthetic, biodegradable polymers that have shown
great potential in vaccine and drug delivery applications. Numerous investigations in …

Vaccination of koalas (Phascolarctos cinereus) with a recombinant chlamydial major outer membrane protein adjuvanted with poly I: C, a host defense peptide and …

SA Khan, C Waugh, G Rawlinson, J Brumm, K Nilsson… - Vaccine, 2014 - Elsevier
Chlamydial infections are wide spread in koalas across their range and a solution to this
debilitating disease has been sought for over a decade. Antibiotics are the currently …

Nano-Assembled Polyphosphazene Delivery System Enables Effective Intranasal Immunization with Nipah Virus Subunit Vaccine

VH Leyva-Grado, A Marin, R Hlushko… - ACS Applied Bio …, 2024 - ACS Publications
The ultimate vaccine against infections caused by Nipah virus should be capable of
providing protection at the respiratory tract─ the most probable port of entry for this …

[PDF][PDF] Potential of nanocarriers in antigen delivery: the path to successful vaccine delivery

P Prabhu, V Patravale - Nanocarriers, 2014 - researchgate.net
Vaccination has indubitably made noteworthy contribution to global health. Recent years
have witnessed the employment of subunit antigens rather than inactivated or live …

[HTML][HTML] PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens

NF Eng, S Garlapati, V Gerdts, LA Babiuk… - Journal of immune …, 2010 - Springer
Background We previously demonstrated that polyphosphazenes, particularly PCEP,
enhance immune responses in mice immunized subcutaneously and intranasally. The …

Intradermal immunization using coated microneedles containing an immunoadjuvant

AK Andrianov, G Mutwiri - Vaccine, 2012 - Elsevier
A vast number of studies explore the potential of intradermal immunization, its role in the
developing of new and improved vaccines and providing access to them globally. The …