Adverse drug events (ADEs) are responsible for a significant number of hospital admissions
and fatalities. Machine learning models have been developed to assess individual patient …

Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma
cruzi. This infection is present in most Latin American countries, although, due to migratory …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Background Chagas disease (CD) remains an important endemic disease in Latin America.
However, CD became globalized in recent decades. The majority of the chronically infected …

Background Infection with Trypanosoma cruzi causes Chagas disease, a major public
health problem throughout Latin America. There is no vaccine and the only drugs have …

Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …

Background Benznidazole is one of the two most effective antiparasitic drugs for Chagas'
disease treatment. However, knowledge about its toxicity profile is mostly based on post …

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …

Background Etiological treatment of Chagas disease in chronic asymptomatic patients is still
in debate and the adverse effects of traditional drugs are one of the main concerns in clinical …

Introduction Chagas disease affects 6–7 million people, mainly in the Americas, and
benznidazole is one of the two therapeutic options available. Trypanocide treatment aims to …