Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …

Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately,
there is no targeted treatment for PNI since the molecular mechanisms are largely unknown …

Abstract The ERK/MAPK and PI3K/Akt signaling pathways play important role in neuronal
survival and axonal regeneration after peripheral nerve injury. However, the relative …

Expression of the neuropeptide galanin is up‐regulated in many brain regions following
nerve injury and in the basal forebrain of patients with Alzheimer's disease. We have …

Discovery of biased ligands and receptor mutants allows characterization of G-protein-and β-
arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However …

Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

Injury to a peripheral nerve induces a complex cellular and molecular response required for
successful axon regeneration. Proliferating Schwann cells organize into chains of cells …

The hypothalamus is a source of neural progenitor cells which give rise to different
populations of specialized and differentiated cells during brain development. Newly formed …