Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic
branching, myelination and other important mechanisms of neural plasticity. Here we review …

Cocaine use continues to be a serious worldwide public health problem. Cocaine abuse is
associated with substantial morbidity and mortality. Cocaine overdose deaths are increasing …

The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated
in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain …

Understanding the changes in the brain which occur in the transition from normal to
addictive behavior has major implications in public health. Here we postulate that while …

A major line of evidence that supports the hypothesis of dopamine overactivity in
schizophrenia is the psychomimetic potential of agents such as amphetamine that stimulate …

Several groups have provided evidence that positron emission tomography (PET) and
single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques …

The authors review the available literature on the preclinical and clinical studies involving
GABAergic neurotransmission in mood disorders. γ-Aminobutyric acid (GABA) is an …

Background: Studies in experimental animals have implicated the mesolimbic dopaminergic
projections into the ventral striatum in the neural processes underlying behavioral …

Objective: The therapeutic effects of methylphenidate in the treatment of attention deficit
disorder have been attributed to its ability to increase the synaptic concentration of …

Abnormalities of dopamine function in schizophrenia are suggested by the common
antidopaminergic properties of antipsychotic medications. However, direct evidence of a …