Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Necroptosis is a programmed, caspase-independent cell death that is morphologically
similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by …

A process of regulated necrosis, termed necroptosis, has been recognized as a major
contributor to cell death and inflammation occurring under a wide range of pathologic …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key
component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as …

Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death through its
kinase activity. However, how its kinase activity is regulated remains poorly understood …

Necroptosis is a kind of programmed necrosis mode that plays a double-edged role in tumor
progression. However, the role of necroptosis-related Messenger RNA (mRNA) in predicting …

Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …

Necroptosis is a programmed form of necrosis characterized by mitochondrial alterations
and plasma membrane permeabilization resulting in the release of cytoplasmic content into …

Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …