Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …

The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by the
immune-mediated destruction of small and medium intrahepatic bile ducts, with variable …

Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of
drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P …

Cellular senescence and biliary fibrosis are prototypical features of obliterative
cholangiopathies, such as primary sclerosing cholangitis (PSC). Telomere dysfunction can …

Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter
cell cycle arrest following DNA damage and other stress signals. Natural, permanent DNA …

Introduction Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease
characterized by the immune-mediated destruction of small and medium intrahepatic bile …

Scope Changes in the intestinal flora are related to autoimmune hepatitis (AIH)
development. The aim of this study is to investigate the synergistic effects of probiotics and …

Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue
damage and in age‐related diseases. Through the production of a multicomponent …

Background: Premature senescence occurs in adult hepatobiliary diseases and worsens the
prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might …