Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative
decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD (P) H, and CO2. IDHs …

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Background Glycolysis plays an essential role in the growth and metastasis of solid cancer
and has received increasing attention in recent years. However, the complex regulatory …

Background Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a
putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation …

Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …