Harnessing human dendritic cell subsets for medicine

H Ueno, N Schmitt, E Klechevsky… - Immunological …, 2010 - Wiley Online Library
Immunity results from a complex interplay between the antigen‐non‐specific innate immune
system and the antigen‐specific adaptive immune system. The cells and molecules of the …

Dendritic cell dysregulation during HIV‐1 infection

E Miller, N Bhardwaj - Immunological reviews, 2013 - Wiley Online Library
Dendritic cells (DC s) are a diverse subset of innate immune cells that are key regulators of
the host response to human immunodeficiency virus‐1 (HIV‐1) infection. HIV‐1 directly and …

A dendritic cell–based vaccine elicits T cell responses associated with control of HIV-1 replication

F García, N Climent, AC Guardo, C Gil, A León… - Science translational …, 2013 - science.org
Combination antiretroviral therapy (cART) greatly improves survival and quality of life of HIV-
1–infected patients; however, cART must be continued indefinitely to prevent viral rebound …

CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse

R Pacheco, JM Martinez-Navio… - Proceedings of the …, 2005 - National Acad Sciences
Adenosine deaminase (ADA), a protein whose deficit leads to severe combined
immunodeficiency, binds to the cell surface by means of either CD26, A1 adenosine …

Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice

KLL Habets, GHM Van Puijvelde… - Cardiovascular …, 2010 - academic.oup.com
Aims Modification of lipoproteins plays an important role in the development of
atherosclerosis. Oxidatively modified low-density lipoprotein (oxLDL) has a number of pro …

A therapeutic dendritic cell-based vaccine for HIV-1 infection

F García, N Climent, L Assoumou, C Gil… - Journal of Infectious …, 2011 - academic.oup.com
A double-blinded, controlled study of vaccination of untreated patients with chronic human
immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte …

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

SD Allard, B De Keersmaecker, AL de Goede… - Clinical …, 2012 - Elsevier
In a phase I/IIa clinical trial, 17 HIV-1 infected patients, stable on cART, received 4
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

JP Routy, MR Boulassel, B Yassine-Diab, C Nicolette… - Clinical …, 2010 - Elsevier
Immunogenicity, manufacturing feasibility, and safety of a novel, autologous dendritic cell
(DC)-based immunotherapy (AGS-004) was evaluated in ten human immunodeficiency virus …

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients

E Van Gulck, E Vlieghe, M Vekemans… - Aids, 2012 - journals.lww.com
Background: In an effort to raise protective antiviral immunity, dendritic cell immunotherapy
was evaluated in six adults infected with human immunodeficiency virus (HIV)-1 and stable …

Clinical trials of antiretroviral treatment interruption in HIV-infected individuals

JSY Lau, MZ Smith, SR Lewin, JH McMahon - Aids, 2019 - journals.lww.com
Despite the benefits of antiretroviral therapy (ART) for people living with HIV, there has been
a long-standing research interest in interrupting ART as a strategy to minimize adverse …