[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Nanog, as a key cancer stem cell marker in tumor progression

P Vasefifar, R Motafakkerazad, LA Maleki, S Najafi… - Gene, 2022 - Elsevier
Cancer stem cells (CSCs) are a small population of malignant cells that induce tumor onset
and development. CSCs share similar features with normal stem cells in the case of self …

Understanding the role of the transcription factor Sp1 in ovarian cancer: from theory to practice

B Vellingiri, M Iyer, M Devi Subramaniam… - International journal of …, 2020 - mdpi.com
Ovarian cancer (OC) is one of the deadliest cancers among women contributing to high risk
of mortality, mainly owing to delayed detection. There is no specific biomarker for its …

NANOG decoy oligodeoxynucleotide–encapsulated niosomes nanocarriers: a promising approach to suppress the metastatic properties of U87 human glioblastoma …

M Gharbavi, B Johari, E Rismani… - ACS Chemical …, 2020 - ACS Publications
Recently, advances in the synthesis and development of multifunctional nanoparticle
platforms have opened up great opportunities and advantages for specifically targeted …

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

X Jiang, L Xing, Y Chen, R Qin, S Song, Y Lu… - … Therapy-Nucleic Acids, 2021 - cell.com
Circular RNA (CircRNA) is a newly identified special class of non-coding RNA (ncRNA) that
plays an important regulatory role in the progression of certain diseases. Herein, our results …

PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin‑3‑gallate in ovarian cancer

J Qin, M Fu, J Wang, F Huang, H Liu… - Oncology …, 2020 - spandidos-publications.com
Abstract Epigallocatechin‑3‑gallate (EGCG), a polyphenol present in green tea, exhibits
anticancer effects in various types of cancer. A number of studies have focused on the …

Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review

M Najafi, S Tavakol, A Zarrabi… - Archives of physiology …, 2022 - Taylor & Francis
Chemotherapy has opened a new window in cancer therapy. However, the resistance of
cancer cells has dramatically reduced the efficacy of chemotherapy. Cisplatin is a …

Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients

R Roudi, M Barodabi, Z Madjd, G Roviello… - Molecular & Cellular …, 2020 - Taylor & Francis
Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-
related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire …

NANOG promotes cell proliferation, invasion, and stemness via IL-6/STAT3 signaling in esophageal squamous carcinoma

L Deng, X Zhang, X Xiang, R Xiong… - … in cancer research …, 2021 - journals.sagepub.com
Background: Cancer cells have properties similar to those of stem cells, including high
proliferation and self-renewal ability. NANOG is the key regulatory gene that maintains the …