Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
[HTML][HTML] Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective
A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …
processes including cell fate determination of vascular endothelial cells and the regulation …
A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2
The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying
asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong …
asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong …
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …
org) is an open‐access database resource that houses manually curated protein and …
Ultrasensitive and specific clustered regularly interspaced short palindromic repeats empowered a plasmonic fiber tip system for amplification-free monkeypox virus …
The urgent necessity for highly sensitive diagnostic tools has been accentuated by the
ongoing mpox (monkeypox) virus pandemic due to the complexity in identifying …
ongoing mpox (monkeypox) virus pandemic due to the complexity in identifying …
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
required for cell entry and is the primary focus for vaccine development. In this study, we …
required for cell entry and is the primary focus for vaccine development. In this study, we …
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation
During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …
disrupting the genes involved in antigen processing and presentation or up-regulating …
[HTML][HTML] Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC
R Saddawi-Konefka, A O'Farrell, F Faraji… - Nature …, 2022 - nature.com
Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain
limited. This raises the possibility that standard of care treatments delivered in concert may …
limited. This raises the possibility that standard of care treatments delivered in concert may …
[HTML][HTML] Promising antiviral activities of natural flavonoids against SARS-CoV-2 targets: systematic review
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …
Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors
R Singh, VK Bhardwaj, J Sharma, D Kumar… - Computers in Biology …, 2021 - Elsevier
The Spike receptor binding domain (S-RBD) from SARS-CoV-2, a crucial protein for the
entrance of the virus into target cells is known to cause infection by binding to a cell surface …
entrance of the virus into target cells is known to cause infection by binding to a cell surface …