Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities

R Cannalire, C Cerchia, AR Beccari… - Journal of medicinal …, 2020 - ACS Publications
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …

[HTML][HTML] Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective

A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

Z Chen, J Li, T Li, T Fan, C Meng, C Li… - National Science …, 2022 - academic.oup.com
The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying
asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong …

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …

Ultrasensitive and specific clustered regularly interspaced short palindromic repeats empowered a plasmonic fiber tip system for amplification-free monkeypox virus …

Y Chen, Z Chen, T Li, M Qiu, J Zhang, Y Wang… - ACS …, 2023 - ACS Publications
The urgent necessity for highly sensitive diagnostic tools has been accentuated by the
ongoing mpox (monkeypox) virus pandemic due to the complexity in identifying …

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

B Turoňová, M Sikora, C Schürmann, WJH Hagen… - Science, 2020 - science.org
The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
required for cell entry and is the primary focus for vaccine development. In this study, we …

The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

TD Martin, RS Patel, DR Cook, MY Choi, A Patil… - Science, 2021 - science.org
During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …

[HTML][HTML] Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC

R Saddawi-Konefka, A O'Farrell, F Faraji… - Nature …, 2022 - nature.com
Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain
limited. This raises the possibility that standard of care treatments delivered in concert may …

[HTML][HTML] Promising antiviral activities of natural flavonoids against SARS-CoV-2 targets: systematic review

R Kaul, P Paul, S Kumar, D Büsselberg… - International journal of …, 2021 - mdpi.com
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …

Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors

R Singh, VK Bhardwaj, J Sharma, D Kumar… - Computers in Biology …, 2021 - Elsevier
The Spike receptor binding domain (S-RBD) from SARS-CoV-2, a crucial protein for the
entrance of the virus into target cells is known to cause infection by binding to a cell surface …