Emerging insights into cellular senescence highlight the relevance of senescence in
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …

Use of high‐resolution micro–computed tomography (µCT) imaging to assess trabecular
and cortical bone morphology has grown immensely. There are several commercially …

Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …

Aging is associated with increased cellular senescence, which is hypothesized to drive the
eventual development of multiple comorbidities. Here we investigate a role for senescent …

Age-related osteoporosis is characterized by the deterioration in bone volume and strength,
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …

Bone marrow‐derived mesenchymal stem cells (BMMSC s) exhibit degenerative changes,
including imbalanced differentiation and reduced proliferation during aging, that contribute …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …

Mice are widely used in studies of skeletal biology, and assessment of their bones by
mechanical testing is a critical step when evaluating the functional effects of an experimental …

Mice are increasingly used for investigation of the pathophysiology of osteoporosis because
their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike …