[HTML][HTML] Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

[HTML][HTML] A recent update on the environment friendly methodologies to synthesize bis (indolyl) methane and 3, 3-di (3-indolyl)-2-indolone derivatives

P Kamboj, V Tyagi - Tetrahedron, 2023 - Elsevier
Indole, widely recognized as a versatile category of heterocyclic frameworks that contain
nitrogen is extensively employed in the synthesis of various organic compounds due to their …

Recent advances in cascade reactions and their mechanistic insights: a concise strategy to synthesize complex natural products and organic scaffolds

G Tiwari, M Kumar, ANS Chauhan… - Organic & Biomolecular …, 2022 - pubs.rsc.org
The beauty of cascade reactions to bestow us with cumbersome organic scaffolds has made
them a cutting-edge area of research. Although the planning of cascades may require …

Advances in organocatalyzed synthesis of organic compounds

A Zafar, MA Iqbal, G Iram, US Shoukat, F Jamil… - RSC …, 2024 - pubs.rsc.org
The recent advancements in utilizing organocatalysts for the synthesis of organic
compounds have been described in this review by focusing on their simplicity, effectiveness …

Synthesis, characterization, and antibacterial activity of novel bis (indolyl) methanes sourced from biorenewable furfurals using gluconic acid aqueous solution (GAAS) …

P Naik, GB Ashoka, AH Seikh, S Dutta - RSC advances, 2024 - pubs.rsc.org
Bis (indolyl) methanes (BIMs) are important heterocycle-containing molecular scaffolds that
show remarkable biological and pharmacological activities. This work reports the synthesis …

Increased catalytic activity through ZnMo7O24/gC3N4 heterostructured assemblies for greener indole condensation reaction at room temperature

N Azizi, E Farhadi, F Farzaneh - Scientific Reports, 2022 - nature.com
As an economical conjugated polymer, graphitic carbon nitride (g-C3N4) has recently
attracted much attention due to its exciting chemical and thermal stability and easy …

[RhCp*Cl2]2-Catalyzed Indole Functionalization: Synthesis of Bioinspired Indole-Fused Polycycles

AN Singh Chauhan, G Mali, G Dua, P Samant… - ACS …, 2023 - ACS Publications
Polycyclic fused indoles are ubiquitous in natural products and pharmaceuticals due to their
immense structural diversity and biological inference, making them suitable for charting …

Transition metal-free efficient synthesis of bis (indolyl) propynes (BIPs)

A Chaturvedi, V Sharma, F Nafla… - Organic & …, 2024 - pubs.rsc.org
A transition metal-free approach has been devised for the synthesis of a variety of bis
(indolyl) propyne (BIP) derivatives. The strategy involves an iodine-catalyzed cascade …

Effective Synthesis and Biological Evaluation of Functionalized 2,3-Dihydrofuro[3,2-c]coumarins via an Imidazole-Catalyzed Green Multicomponent Approach

G Mali, S Maji, KA Chavan, M Shukla, M Kumar… - ACS …, 2022 - ACS Publications
For the first time, an eco-friendly and efficient one-pot green multicomponent approach has
been described to synthesize functionalized trans-2, 3-dihydrofuro [3, 2-c] coumarins …

Mitotic Functions and Characters of KIF11 in Cancers

W Gao, J Lu, Z Yang, E Li, Y Cao, L Xie - Biomolecules, 2024 - mdpi.com
Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely
related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the …