The expanding world of tRNA modifications and their disease relevance
T Suzuki - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
The Candida pathogenic species complex
Candida species are the most common causes of fungal infection. Approximately 90% of
infections are caused by five species: Candida albicans, Candida glabrata, Candida …
infections are caused by five species: Candida albicans, Candida glabrata, Candida …
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been
difficult in part because a simple method to simultaneously quantify their abundance and …
difficult in part because a simple method to simultaneously quantify their abundance and …
Universal rules and idiosyncratic features in tRNA identity
R Giegé, M Sissler, C Florentz - Nucleic acids research, 1998 - academic.oup.com
Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …
Origin and evolution of the genetic code: the universal enigma
EV Koonin, AS Novozhilov - IUBMB life, 2009 - Wiley Online Library
The genetic code is nearly universal, and the arrangement of the codons in the standard
codon table is highly nonrandom. The three main concepts on the origin and evolution of the …
codon table is highly nonrandom. The three main concepts on the origin and evolution of the …
Natural expansion of the genetic code
A Ambrogelly, S Palioura, D Söll - Nature chemical biology, 2007 - nature.com
At the time of its discovery four decades ago, the genetic code was viewed as the result of a
“frozen accident.” Our current knowledge of the translation process and of the detailed …
“frozen accident.” Our current knowledge of the translation process and of the detailed …
tRNomics: analysis of tRNA genes from 50 genomes of Eukarya, Archaea, and Bacteria reveals anticodon-sparing strategies and domain-specific features
C Marck, H Grosjean - Rna, 2002 - cambridge.org
From 50 genomes of the three domains of life (7 eukarya, 13 archaea, and 30 bacteria), we
extracted, analyzed, and compared over 4,000 sequences corresponding to cytoplasmic …
extracted, analyzed, and compared over 4,000 sequences corresponding to cytoplasmic …
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
Y Kirino, T Yasukawa, S Ohta, S Akira… - Proceedings of the …, 2004 - National Acad Sciences
Point mutations in the mitochondrial (mt) tRNALeu (UUR) gene are responsible for
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) …
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) …
Modification defect at anticodon wobble nucleotide of mitochondrial tRNAsLeu (UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic …
The mitochondrial tRNA Leu (UUR)(R= A or G) gene possesses several hot spots for
pathogenic mutations. A point mutation at nucleotide position 3243 or 3271 is associated …
pathogenic mutations. A point mutation at nucleotide position 3243 or 3271 is associated …
[HTML][HTML] Molecular epidemiology, phylogeny and evolution of Candida albicans
BA McManus, DC Coleman - Infection, Genetics and Evolution, 2014 - Elsevier
A small number of Candida species form part of the normal microbial flora of mucosal
surfaces in humans and may give rise to opportunistic infections when host defences are …
surfaces in humans and may give rise to opportunistic infections when host defences are …