Cells can respond to stress in various ways ranging from the activation of survival pathways
to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork
protection. Defects in these functions cause genomic instability and tumorigenesis but also …

Although RNA and RNA-binding proteins have been linked to double-strand breaks (DSBs),
little is known regarding their roles in the cellular response to DSBs and, if any, in the repair …

SSB proteins bind to and control the accessibility of single-stranded DNA (ssDNA), likely
facilitated by their ability to diffuse on ssDNA. Using a hybrid single-molecule method …

The formation of heteroduplex DNA is a central step in the exchange of DNA sequences via
homologous recombination, and in the accurate repair of broken chromosomes via …

Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the
exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during …

Damage to genetic material represents a persistent and ubiquitous threat to genomic
stability. Once DNA damage is detected, a multifaceted signaling network is activated that …

Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which
specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is …