A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR

R Bilger, A Migur, A Wulf, C Steglich, H Urlaub… - Cell Reports, 2024 - cell.com
How CRISPR-Cas systems defend bacteria and archaea against invading genetic elements
is well understood, but less is known about their regulation. In the cyanobacterium …

CRISPR-RNA binding drives structural ordering that primes Cas7-11 for target cleavage

CP Lin, H Li, DJ Brogan, T Wang, OS Akbari… - bioRxiv, 2024 - biorxiv.org
ABSTRACT Type III-E CRISPR-Cas effectors, referred to as Cas7-11 of gRAMPs, are single
proteins that cleave target RNAs without nonspecific collateral cleavage, opening new …

Membrane bound geranylated RNAs establish a primitive peptide synthesis system

CY Chan, J Singer, T Carell - bioRxiv, 2024 - biorxiv.org
The origin of an RNA-based translation system necessitates a specific interaction of certain
RNAs with defined amino acids. This must have happened in a protocellular environment …