The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Ca2+ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis

FC Tsai, GH Kuo, SW Chang… - BioMed research …, 2015 - Wiley Online Library
Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for
embryonic development, wound healing, and cancer metastasis. However, how Ca2+ …

The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels

CY Park, A Shcheglovitov, R Dolmetsch - Science, 2010 - science.org
Voltage-and store-operated calcium (Ca2+) channels are the major routes of Ca2+ entry in
mammalian cells, but little is known about how cells coordinate the activity of these channels …

The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation

PSB Finnie, K Nader - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …

Calcium, bioenergetics, and Parkinson's disease

E Zampese, DJ Surmeier - Cells, 2020 - mdpi.com
Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for
the core motor deficits of Parkinson's disease (PD). These neurons are autonomous …

[HTML][HTML] From gene to behavior: L-type calcium channel mechanisms underlying neuropsychiatric symptoms

ZD Kabir, A Martínez-Rivera, AM Rajadhyaksha - Neurotherapeutics, 2017 - Elsevier
The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

Voltage-gated calcium channels: key players in sensory coding in the retina and the inner ear

T Pangrsic, JH Singer, A Koschak - Physiological reviews, 2018 - journals.physiology.org
Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

[图书][B] Handbook of basal ganglia structure and function

H Steiner, KY Tseng - 2016 - books.google.com
Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated
overview of the structural and functional aspects of the basal ganglia, highlighting clinical …

Calcium channel functions in pain processing

J Park, ZD Luo - Channels, 2010 - Taylor & Francis
Voltage-gated calcium channels (VGCC) play obligatory physiological roles, including
modulation of neuronal functions, synaptic plasticity, neurotransmitter release and gene …

The role of auxiliary subunits for the functional diversity of voltage‐gated calcium channels

M Campiglio, BE Flucher - Journal of cellular physiology, 2015 - Wiley Online Library
Voltage‐gated calcium channels (VGCCs) represent the sole mechanism to convert
membrane depolarization into cellular functions like secretion, contraction, or gene …