Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease
Background: The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
[HTML][HTML] Current state of Alzheimer's fluid biomarkers
JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …
heterogeneous pathophysiology. The number of people living with AD is predicted to …
[HTML][HTML] Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
[HTML][HTML] Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …
alter dementia onset. Mixed results are emerging from prior observational studies. To …
Alzheimer's diseases detection by using deep learning algorithms: a mini-review
S Al-Shoukry, TH Rassem, NM Makbol - IEEE Access, 2020 - ieeexplore.ieee.org
The accurate diagnosis of Alzheimer's disease (AD) plays an important role in patient
treatment, especially at the disease's early stages, because risk awareness allows the …
treatment, especially at the disease's early stages, because risk awareness allows the …
CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels
Abstract Development of disease-modifying therapies against Alzheimer's disease (AD)
requires biomarkers reflecting the diverse pathological pathways specific for AD. We …
requires biomarkers reflecting the diverse pathological pathways specific for AD. We …
[HTML][HTML] Cerebrospinal fluid biomarkers of Alzheimer's disease: current evidence and future perspectives
DA McGrowder, F Miller, K Vaz, C Nwokocha… - Brain sciences, 2021 - mdpi.com
Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …
neurodegenerative disease characterized by a decline in cognition. Over the last two …
Role of tau in various tauopathies, treatment approaches, and emerging role of nanotechnology in neurodegenerative disorders
A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …
Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia refers to a group of neurodegenerative disorders characterized by
behaviour and language alterations and focal brain atrophy. Amyotrophic lateral sclerosis is …
behaviour and language alterations and focal brain atrophy. Amyotrophic lateral sclerosis is …
[HTML][HTML] Traditional Chinese medicine for anti-Alzheimer's disease: berberine and evodiamine from Evodia rutaecarpa
Z Fang, Y Tang, J Ying, C Tang, Q Wang - Chinese medicine, 2020 - Springer
Alzheimer's disease (AD) is one of the most common diseases in elderly people with a high
incidence of dementia at approximately 60–80%. The pathogenesis of AD was quite …
incidence of dementia at approximately 60–80%. The pathogenesis of AD was quite …