Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy
AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
[HTML][HTML] Mitochondria in cancer
D Grasso, LX Zampieri, T Capelôa, JA Van de Velde… - Cell stress, 2020 - ncbi.nlm.nih.gov
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
[HTML][HTML] Targeting metabolism in cancer cells and the tumour microenvironment for cancer therapy
Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …
treatment. The metabolic reprogramming that accompanies the development of malignancy …
[HTML][HTML] T-cells produce acidic niches in lymph nodes to suppress their own effector functions
H Wu, V Estrella, M Beatty, D Abrahams… - Nature …, 2020 - nature.com
The acidic pH of tumors profoundly inhibits effector functions of activated CD8+ T-cells. We
hypothesize that this is a physiological process in immune regulation, and that it occurs …
hypothesize that this is a physiological process in immune regulation, and that it occurs …
[HTML][HTML] Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and …
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
[HTML][HTML] A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria …
The present review is a sequel to the previous review on cancer metabolism published in
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
this journal. This review focuses on the selective antiproliferative and cytotoxic effects of …
Mitochondria-targeted analogues of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells
Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …
[HTML][HTML] Preventing allograft rejection by targeting immune metabolism
Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic
machinery necessary to proliferate and sustain effector function. This metabolic …
machinery necessary to proliferate and sustain effector function. This metabolic …
[HTML][HTML] Bioenergetic adaptations in chemoresistant ovarian cancer cells
Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and
mainly derive their cellular energy from aerobic glycolysis rather than oxidative …
mainly derive their cellular energy from aerobic glycolysis rather than oxidative …