During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Activation of the intrinsic pathway of coagulation contributes to the pathogenesis of arterial
and venous thrombosis. Critical insights into the involvement of intrinsic pathway factors …

The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized
biochemical pathways that include several proteins that skirt the fringes of the blood …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

The population history of Aboriginal Australians remains largely uncharacterized. Here we
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama …

Reactive and clonal neutrophil expansion has been associated with thrombosis, suggesting
that neutrophils play a role in this process. However, although there is no doubt that …

The contact system, also named as plasma kallikrein-kinin system, consists of three serine
proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and …

Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally–induced
thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
(coronavirus disease 2019; COVID-19) is associated with adverse outcomes in patients with …