Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

New experimental results on collagen fibre dispersion in human arterial layers have shown
that the dispersion in the tangential plane is more significant than that out of plane. A …

Aortic disease is a significant cause of death in developed countries. The most common
forms of aortic disease are aneurysm, dissection, atherosclerotic occlusion and ageing …

Aortic dissections and aortic aneurysms are fatal events characterized by structural changes
to the aortic wall. The maximum diameter criterion, typically used for aneurysm rupture risk …

Biomechanical factors play fundamental roles in the natural history of abdominal aortic
aneurysms (AAAs) and their responses to treatment. Advances during the past two decades …

Collagen fibres within fibrous soft biological tissues such as artery walls, cartilage,
myocardiums, corneas and heart valves are responsible for their anisotropic mechanical …

Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled
by a ground matrix and embedded families of collagen fibres. Changes in the structural …

Soft biological tissues are complex materials with a large structural variety, with differences
in behavior, but with some common characteristics. Skin is an archetypal soft tissue which …