Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
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Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
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Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof
F Zhang, O Shalem, NE Sanjana, J Doench… - US Patent …, 2020 - Google Patents
The present invention generally relates to libraries, compositions, methods, applications, kits
and screens used in functional genomics that focus on gene function in a cell and that may …
and screens used in functional genomics that focus on gene function in a cell and that may …
Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results …
F Zhang, Y Li, DA Scott, JA Weinstein… - US Patent 10,930,367, 2021 - Google Patents
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Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
F Zhang, L Cong, RAN Fei, M Heidenreich… - US Patent …, 2021 - Google Patents
2020-05-07 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
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Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
F Zhang, C Lin, RAN Fei - US Patent 11,008,588, 2021 - Google Patents
2016-06-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
B Davidson, C Lin, E Rodriguez, F Zhang - 2015 - Google Patents
WO2015089354A1 - Compositions and methods of use of crispr-cas systems in nucleotide
repeat disorders - Google Patents WO2015089354A1 - Compositions and methods of use of …
repeat disorders - Google Patents WO2015089354A1 - Compositions and methods of use of …
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for genome editing
2016-09-28 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Protected guide rnas (pgrnas)
The invention provides for systems, methods, and compositions for altering expression of
target gene sequences and related gene products. Provided are structural information on …
target gene sequences and related gene products. Provided are structural information on …
Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation
2018-07-16 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …