Many bioactive natural products synthesized by actinomycetes are glycosylated compounds
in which the appended sugars contribute to specific interactions with their biological target …

The indolocarbazole staurosporine is a potent inhibitor of a variety of protein kinases. It
contains a sugar moiety attached through C‐N linkages to both indole nitrogen atoms of the …

Riboflavin analogs have a good potential to serve as basic structures for the development of
novel anti-infectives. Riboflavin analogs have multiple cellular targets, since riboflavin (as a …

Macrolides are a class of valuable antibiotics that include a macrolactone ring, at least one
appended sugar unit, and, in most cases, additional hydroxyl or epoxide groups installed by …

A biocatalytic platform that employs the final two monomodular type I polyketide synthases of
the pikromycin pathway in vitro followed by direct appendage of d-desosamine and final C …

Forosamine (4-dimethylamino)-2, 3, 4, 6-tetradeoxy-β-d-threo-hexopyranose) is a highly
deoxygenated sugar component of several important natural products, including the potent …

Sugar biosynthesis cassette genes have been used to construct plasmids directing the
biosynthesis of branched-chain deoxysugars: pFL942 (NDP-L-mycarose), pFL947 (NDP-4 …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and
is an active ingredient in several commercial insecticides. It is glycosylated by a tri-O …

d-Desosamine (1) is a 3-(N, N-dimethylamino)-3, 4, 6-trideoxyhexose found in a number of
macrolide antibiotics including methymycin (2), neomethymycin (3), pikromycin (4), and …