Understanding plant pathogen interactions using spatial and single-cell technologies
Plants are in contact with diverse pathogens and microorganisms. Intense investigation over
the last 30 years has resulted in the identification of multiple immune receptors in model and …
the last 30 years has resulted in the identification of multiple immune receptors in model and …
Scalable single-cell profiling of chromatin modifications with sciCUT&Tag
DH Janssens, JE Greene, SJ Wu, CA Codomo… - Nature …, 2024 - nature.com
Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …
[HTML][HTML] A single-cell time-lapse of mouse prenatal development from gastrula to birth
The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
We set out to exhaustively characterize the impact of the cis-chromatin environment on
prime editing, a precise genome engineering tool. Using a highly sensitive method for …
prime editing, a precise genome engineering tool. Using a highly sensitive method for …
A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains
A Sziraki, Z Lu, J Lee, G Banyai, S Anderson… - Nature Genetics, 2023 - nature.com
Conventional methods fall short in unraveling the dynamics of rare cell types related to
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …
Multiplex profiling of developmental cis-regulatory elements with quantitative single-cell expression reporters
The inability to scalably and precisely measure the activity of developmental cis-regulatory
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …
Retinoic acid induces human gastruloids with posterior embryo-like structures
Gastruloids are a powerful in vitro model of early human development. However, although
elongated and composed of all three germ layers, human gastruloids do not morphologically …
elongated and composed of all three germ layers, human gastruloids do not morphologically …
Four Core Genotypes mice harbour a 3.2MB XY translocation that perturbs Tlr7 dosage
Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the
function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the …
function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the …
Recent Progress in MOF‐Aerogel Fabrication and Applications
T Guo, H Mashhadimoslem, L Choopani, MM Salehi… - Small, 2024 - Wiley Online Library
Recent advancements in metal–organic frameworks (MOFs) underscore their significant
potential in chemical and materials research, owing to their remarkable properties and …
potential in chemical and materials research, owing to their remarkable properties and …
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy
A large-scale multimodal atlas that includes major kidney regions is lacking. Here, we
employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) …
employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) …