Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies
affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular …

It is increasingly acknowledged that a sex and gender specificity affects the occurrence,
development, and consequence of a plethora of pathologies. Mitochondria are considered …

There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Mitochondrial function is an important determinant of the ageing process; however, the
mitochondrial properties that enable longevity are not well understood. Here we show that …

Oxidative stress is observed during aging and in numerous age-related diseases. Dietary
restriction (DR) is a regimen that protects against disease and extends life span in multiple …

The Mitochondrial Free Radical Theory of Aging (MFRTA) proposes that mitochondrial free
radicals, produced as by-products during normal metabolism, cause oxidative damage …

Paraoxonase 2 (PON2), a member of a gene family that also includes PON1 and PON3, is
expressed in most tissues, including the brain. In mouse brain, PON2 levels are highest in …

Background and Aims A novel bioactive peptide, mitochondrial‐derived peptide (MOTS‐c),
has recently attracted attention as a potential prevention or therapeutic option for obesity …