The invisible string of coagulation, complement, iron, and inflammation in sickle cell disease
JD Beckman, EM Sparkenbaugh - Current opinion in hematology, 2023 - journals.lww.com
Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …
VWF–ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion
Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …
Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice
Although it is caused by a single-nucleotide mutation in the β-globin gene, sickle cell
anemia (SCA) is a systemic disease with complex, incompletely elucidated pathologies. The …
anemia (SCA) is a systemic disease with complex, incompletely elucidated pathologies. The …