Our understanding of the genetic basis of systemic lupus erythematosus has progressed
rapidly in recent years. While many genetic polymorphisms have been associated with …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of
autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and …

Introduction: Multiple pathways are involved in the pathogenesis of systemic lupus
erythematosus (SLE). The Janus kinase-signal transducers and activators of transcription …

Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues,
predominantly the synovial joints. The pathogenesis of this disease is not completely …

Autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis
and inflammatory bowel disease, have complex pathogeneses and the factors which cause …

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with complex
pathogenesis in which genes and environmental factors are involved. We aimed at …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. As with other
complex traits, genome-wide association studies (GWASs) have tremendously enhanced …

Genetics unquestionably contributes to systemic lupus erythematosus (SLE) predisposition,
progression and outcome. Nevertheless, single-gene defects causing lupus-like phenotypes …

Rheumatoid arthritis (RA) is a systemic autoimmune disease resulting in chronic
inflammation of the synovium and consequent cartilage and bone erosion. RA is associated …