MHC genotypes associate with resistance to a frog-killing fungus

AE Savage, KR Zamudio - Proceedings of the National …, 2011 - National Acad Sciences
The emerging amphibian disease chytridiomycosis is caused by the fungal pathogen
Batrachochytrium dendrobatidis (Bd). Amphibian populations and species differ in …

Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations

AE Savage, KR Zamudio - Proceedings of the Royal …, 2016 - royalsocietypublishing.org
Amphibians have been affected globally by the disease chytridiomycosis, caused by the
fungus Batrachochytrium dendrobatidis (Bd), and we are just now beginning to understand …

Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation

A Bataille, SD Cashins, L Grogan… - … of the Royal …, 2015 - royalsocietypublishing.org
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous
population declines in its amphibian hosts. Responses of individuals to infection vary greatly …

[图书][B] Evolutionary conservation genetics

J Höglund - 2009 - books.google.com
Conservation genetics focuses on understanding the role and requirement of genetic
variation for population persistence. However, considerable debate now surrounds the role …

Interspecific hybridization increases MHC class II diversity in two sister species of newts

K NADACHOWSKA‐BRZYSKA, P Zieliński… - Molecular …, 2012 - Wiley Online Library
Our understanding of the evolutionary mechanisms generating variation within the highly
polymorphic major histocompatibility complex (MHC) genes remains incomplete. Assessing …

Contrasting patterns of variation in MHC loci in the Alpine newt

W Babik, M Pabijan, J Radwan - Molecular ecology, 2008 - Wiley Online Library
Major histocompatibility complex (MHC) genes are essential in pathogen recognition and
triggering an adaptive immune response. Although they are the most polymorphic genes in …

Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication

KM Kiemnec-Tyburczy, JQ Richmond, AE Savage… - Heredity, 2012 - nature.com
Comparative studies of major histocompatibility complex (MHC) genes across vertebrate
species can reveal the evolutionary processes that shape the structure and function of …

Selection, trans-species polymorphism, and locus identification of major histocompatibility complex class IIβ alleles of New World ranid frogs

KM Kiemnec-Tyburczy, JQ Richmond, AE Savage… - Immunogenetics, 2010 - Springer
Genes encoded by the major histocompatibility complex (MHC) play key roles in the
vertebrate immune system. However, our understanding of the evolutionary processes and …

Conservation and divergence in the frog immunome: pyrosequencing and de novo assembly of immune tissue transcriptomes

AE Savage, KM Kiemnec-Tyburczy, AR Ellison… - Gene, 2014 - Elsevier
Background Frogs are a diverse group of vertebrates for which limited genomic resources
are available. Natural frog populations face a multitude of threats, including habitat …

Drift Rather than Selection Dominates MHC Class II Allelic Diversity Patterns at the Biogeographical Range Scale in Natterjack Toads Bufo calamita

I Zeisset, TJC Beebee - PLoS One, 2014 - journals.plos.org
Study of major histocompatibility complex (MHC) loci has gained great popularity in recent
years, partly due to their function in protecting vertebrates from infections. This is of particular …