Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety
of purposes, including its most common use as an anti-inflammatory agent. It has been well …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that
have been used recently to reduce tubular absorption of glucose, leading to enhanced …

Background: In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase
(CSE), generates hydrogen sulfide–related sulfane sulfur compounds (H2Sn), that exert …

The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

Background Oxidative stress and muscle damage occur during exhaustive bouts of exercise,
and many runners report pain and soreness as major influences on changes or breaks in …

Significance: Changes in the oxidative balance can affect cellular physiology and adaptation
through redox signaling. The endothelial cells that line blood vessels are particularly …

Reactive oxygen species (ROS) play critical roles in normal physiological processes
including cellular signaling and immune responses. Various pathological conditions …

Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure,
which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disease of the lung tissue that
causes symptoms such as coughing and asthma. It is caused by inflammatory factors and …

Hypoxia-induced oxidative stress and excessive proliferation of pulmonary artery smooth
muscle cells (PASMCs) play important roles in the pathological process of hypoxic …