Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

The red-pigmented prodiginines are bioactive secondary metabolites produced by both
Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have …

RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …

Profound changes are occurring in the strategies that biotechnology-based industries are
deploying in the search for exploitable biology and to discover new products and develop …

Members of the soil‐dwelling prokaryotic genus Streptomyces produce many secondary
metabolites, including antibiotics and anti‐tumour agents. Their formation is coupled with the …

The stringent response utilizes hyperphosphorylated guanine [(p) ppGpp] as a signaling
molecule to control bacterial gene expression involved in long-term survival under starvation …

A strain of Streptomyces lividans, TK24, was found to produce a pigmented antibiotic,
actinorhodin, although S. lividans normally does not produce this antibiotic. Genetic …

Streptomycetes are Gram-positive bacteria with a unique capacity for the production of a
multitude of varied and complex secondary metabolites. They also have a complex life cycle …

Deletion of most of the coding region of the ppGpp synthetase gene (relA) of Streptomyces
coelicolor A3 (2) resulted in loss of ppGpp synthesis, both upon entry into stationary phase …

Catalytic and regulatory domains of the Rel/Spo homolog of Streptococcus equisimilis
affecting (p) ppGpp synthesis and degradation activities have been defined, and opposing …