Prospects for antibacterial discovery and development
TM Privalsky, AM Soohoo, J Wang… - Journal of the …, 2021 - ACS Publications
The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …
be countered through renewed investment in the discovery and development of antibiotics …
Anti-tuberculosis Mur inhibitors: structural insights and the way ahead for development of novel agents
Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …
The mur enzymes chink in the armour of Mycobacterium tuberculosis cell wall
Tuberculosis (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
Computational target-based screening of anti-MRSA natural products reveals potential multitarget mechanisms of action through peptidoglycan synthesis proteins
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of bacterial
infections in both healthcare and community settings. MRSA can acquire resistance to any …
infections in both healthcare and community settings. MRSA can acquire resistance to any …
[HTML][HTML] Screening and molecular dynamics simulation of compounds inhibiting MurB enzyme of drug-resistant Mycobacterium tuberculosis: An in-silico approach
Mycobacterium tuberculosis (MTB) is becoming more and more resistant to drugs and it is a
common problem, making current antimicrobials ineffective and highlighting the need for …
common problem, making current antimicrobials ineffective and highlighting the need for …
Recent progress in the development of novel mycobacterium cell wall inhibitor to combat drug-resistant tuberculosis
TM Belete - Microbiology Insights, 2022 - journals.sagepub.com
Despite decades of research in drug development against TB, it is still the leading cause of
death due to infectious diseases. The long treatment duration, patient noncompliance …
death due to infectious diseases. The long treatment duration, patient noncompliance …
Emerging extracellular molecular targets for innovative pharmacological approaches to resistant Mtb infection
Emerging pharmacological strategies that target major virulence factors of antibiotic-
resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is …
resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is …
Design and Synthesis of Various 5′-Deoxy-5′-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of Mycobacterium tuberculosis Mur Ligases
V Hervin, R Arora, J Rani, S Ramchandran, U Bajpai… - Molecules, 2020 - mdpi.com
The synthesis of hitherto unknown 5′-deoxy-5′-(4-substituted-1, 2, 3-triazol-1-yl)-uridine
and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved …
and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved …
A high content screening assay for discovery of antimycobacterial compounds based on primary human macrophages infected with virulent Mycobacterium …
Drug resistance in Mycobacterium tuberculosis is an emerging threat that makes the
discovery of new candidate drugs a priority. In particular, drugs with high sterilizing activity …
discovery of new candidate drugs a priority. In particular, drugs with high sterilizing activity …
Screening of potential phytomolecules against MurG as drug target in nosocomial pathogen Pseudomonas aeruginosa: perceptions from computational campaign
KB Lokhande, SV Pawar, S Madkaiker… - Journal of …, 2024 - Taylor & Francis
The nosocomial infection outbreak caused by Pseudomonas aeruginosa remains a public
health concern. Multi-drug resistant (MDR) strains of P. aeruginosa are rapidly spreading …
health concern. Multi-drug resistant (MDR) strains of P. aeruginosa are rapidly spreading …