A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

Abstract TCRαβ+ CD3+ CD4− CD8−“double negative”(DN) T cells comprise a small subset
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …

T lymphocytes, which are central players in orchestrating immune responses, consist of
several subtypes with distinct functions. The thymus is an organ where hematopoietic …

Autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF)
syndrome is mainly characterized by recurrent, often fatal, respiratory and gastrointestinal …

" The beginning of wisdom is found in doubting; by doubting we come to question, and by
seeking we may come upon the truth."–Pierre Abélard CD8 is a glycoprotein expressed on …

Natural killer (NK) cells are innate lymphocytes that exhibit many features of adaptive
immunity, including clonal proliferation and long-lived memory. Here we demonstrate that …

The germinal center (GC) is a unique histological structure found in peripheral lymphoid
organs. GCs provide an important source of humoral immunity by generating high affinity …

During thymic development, thymocytes expressing a T cell receptor consisting of an alpha
and beta chain (TCRαβ), commit to either the cytotoxic-or T helper-lineage fate. This lineage …