A two‐stage adaptive clinical trial design with data‐driven subgroup identification at interim analysis
SE Johnston, I Lipkovich, A Dmitrienko… - Pharmaceutical …, 2022 - Wiley Online Library
In this paper, we consider randomized controlled clinical trials comparing two treatments in
efficacy assessment using a time to event outcome. We assume a relatively small number of …
efficacy assessment using a time to event outcome. We assume a relatively small number of …
Two-Stage Adaptive Design with Data-Driven Subgroup Identification and Expected Utility
SE Johnston - 2021 - search.proquest.com
This research considers randomized controlled clinical trials comparing two treatments in
efficacy assessment using a time-to-event outcome. The research assumes a relatively small …
efficacy assessment using a time-to-event outcome. The research assumes a relatively small …
[PDF][PDF] Statistical Methods in Clinical Trial Design
Y Du - 2018 - jscholarship.library.jhu.edu
Numerous human medical problems or diseases have been aided by the development of
effective treatments such as drugs and medical devices. Clinical trials are an integral part of …
effective treatments such as drugs and medical devices. Clinical trials are an integral part of …