Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering

J Beld, DJ Lee, MD Burkart - Molecular BioSystems, 2015 - pubs.rsc.org
Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

Plant monounsaturated fatty acids: Diversity, biosynthesis, functions and uses

S Kazaz, R Miray, L Lepiniec, S Baud - Progress in lipid research, 2022 - Elsevier
Monounsaturated fatty acids are straight-chain aliphatic monocarboxylic acids comprising a
unique carbon‑carbon double bond, also termed unsaturation. More than 50 distinct …

A β-Ketoacyl-CoA Synthase Is Involved in Rice Leaf Cuticular Wax Synthesis and Requires a CER2-LIKE Protein as a Cofactor

X Wang, Y Guan, D Zhang, X Dong, L Tian… - Plant …, 2017 - academic.oup.com
Cuticular waxes are complex mixtures of very-long-chain fatty acids (VLCFAs) and their
derivatives, forming a natural barrier on aerial surfaces of terrestrial plants against biotic and …

A review of nervonic acid production in plants: prospects for the genetic engineering of high nervonic acid cultivars plants

F Liu, P Wang, X Xiong, X Zeng, X Zhang… - Frontiers in Plant …, 2021 - frontiersin.org
Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid that plays crucial roles in
brain development and has attracted widespread research interest. The markets …

Mining fatty acid biosynthesis for new antimicrobials

CD Radka, CO Rock - Annual review of microbiology, 2022 - annualreviews.org
Antibiotic resistance is a serious public health concern, and new drugs are needed to
ensure effective treatment of many bacterial infections. Bacterial type II fatty acid synthesis …

Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature

M Dell, KL Dunbar, C Hertweck - Natural product reports, 2022 - pubs.rsc.org
The first machineries for non-ribosomal peptide (NRP) biosynthesis were uncovered over 50
years ago, and the dissection of these megasynthetases set the stage for the nomenclature …

Molecular Programming of Drought-Challenged Trichoderma harzianum-Bioprimed Rice (Oryza sativa L.)

BM Bashyal, P Parmar, NW Zaidi… - Frontiers in …, 2021 - frontiersin.org
Trichoderma biopriming enhances rice growth in drought-stressed soils by triggering various
plant metabolic pathways related to antioxidative defense, secondary metabolites, and …

H-bonded reusable template assisted para-selective ketonisation using soft electrophilic vinyl ethers

A Maji, A Dahiya, G Lu, T Bhattacharya… - Nature …, 2018 - nature.com
In nature, enzymatic pathways generate Caryl− C (O) bonds in a site-selective fashion.
Synthetically, Caryl− C (O) bonds are synthesised in organometallic reactions using …

Production of Medium Chain Fatty Acids by Yarrowia lipolytica: Combining Molecular Design and TALEN to Engineer the Fatty Acid Synthase

C Rigouin, M Gueroult, C Croux, G Dubois… - ACS synthetic …, 2017 - ACS Publications
Yarrowia lipolytica is a promising organism for the production of lipids of biotechnological
interest and particularly for biofuel. In this study, we engineered the key enzyme involved in …

Evolutionary conserved function of barley and Arabidopsis 3-KETOACYL-CoA SYNTHASES in providing wax signals for germination of powdery mildew fungi

D Weidenbach, M Jansen, RB Franke… - Plant …, 2014 - academic.oup.com
For plant pathogenic fungi, such as powdery mildews, that survive only on a limited number
of host plant species, it is a matter of vital importance that their spores sense that they landed …