The role of macrophage subtypes and exosomes in immunomodulation
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …
polarized by different microenvironment signals. Cell polarization leads to a wide range of …
Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …
Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via …
J Chen, K Zhang, Y Zhi, Y Wu, B Chen… - Clinical and …, 2021 - Wiley Online Library
Numerous reports have elucidated the important participation of exosomes in the
communication between tumor cells and other cancer‐related cells including tumor …
communication between tumor cells and other cancer‐related cells including tumor …
[HTML][HTML] Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer
Y Wang, Y Wang, Y Ren, Q Zhang, P Yi… - Seminars in cancer …, 2022 - Elsevier
Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …
M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5 …
H Jiang, L Zhou, N Shen, X Ning, D Wu, K Jiang… - Cell death & …, 2022 - nature.com
Exosomes serve as a crucial mode of communication between tumor-associated
macrophages (TAMs) and cancer cells. This study attempted to explore the function of M1 …
macrophages (TAMs) and cancer cells. This study attempted to explore the function of M1 …
Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma
M Swamydas, EV Murphy, JJ Ignatz-Hoover… - Journal of Hematology & …, 2022 - Springer
Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …
Exosomes as mediators of immune regulation and immunotherapy in cancer
FG Kugeratski, R Kalluri - The FEBS Journal, 2021 - Wiley Online Library
Exosomes are nanosized extracellular vesicles of endosomal origin that enclose a multitude
of functional biomolecules. Exosomes have emerged as key players of intercellular …
of functional biomolecules. Exosomes have emerged as key players of intercellular …
Next frontier in tumor immunotherapy: macrophage-mediated immune evasion
Y Qiu, T Chen, R Hu, R Zhu, C Li, Y Ruan, X Xie… - Biomarker research, 2021 - Springer
Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …
Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine
D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …
biomembranes, such as natural cell membranes or subcellular structure-derived …
[HTML][HTML] Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway
W Zhang, X Zheng, Y Yu, L Zheng, J Lan… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Tumor-derived exosomes play a pivotal role in regulating tumor progression by mediating
crosstalk between tumor cells and immune cells such as macrophages within the tumor …
crosstalk between tumor cells and immune cells such as macrophages within the tumor …