The role of macrophage subtypes and exosomes in immunomodulation

AT Gharavi, NA Hanjani, E Movahed… - Cellular & molecular …, 2022 - Springer
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via …

J Chen, K Zhang, Y Zhi, Y Wu, B Chen… - Clinical and …, 2021 - Wiley Online Library
Numerous reports have elucidated the important participation of exosomes in the
communication between tumor cells and other cancer‐related cells including tumor …

[HTML][HTML] Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer

Y Wang, Y Wang, Y Ren, Q Zhang, P Yi… - Seminars in cancer …, 2022 - Elsevier
Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5 …

H Jiang, L Zhou, N Shen, X Ning, D Wu, K Jiang… - Cell death & …, 2022 - nature.com
Exosomes serve as a crucial mode of communication between tumor-associated
macrophages (TAMs) and cancer cells. This study attempted to explore the function of M1 …

Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma

M Swamydas, EV Murphy, JJ Ignatz-Hoover… - Journal of Hematology & …, 2022 - Springer
Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …

Exosomes as mediators of immune regulation and immunotherapy in cancer

FG Kugeratski, R Kalluri - The FEBS Journal, 2021 - Wiley Online Library
Exosomes are nanosized extracellular vesicles of endosomal origin that enclose a multitude
of functional biomolecules. Exosomes have emerged as key players of intercellular …

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Y Qiu, T Chen, R Hu, R Zhu, C Li, Y Ruan, X Xie… - Biomarker research, 2021 - Springer
Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …

[HTML][HTML] Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway

W Zhang, X Zheng, Y Yu, L Zheng, J Lan… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Tumor-derived exosomes play a pivotal role in regulating tumor progression by mediating
crosstalk between tumor cells and immune cells such as macrophages within the tumor …