Excited (triplet) states offer a myriad of attractive synthetic pathways, including
cycloadditions, selective homolytic bond cleavages and strain-release chemistry …

The merger of photoredox catalysis with transition metal catalysis, termed
metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past …

Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Geometrical E→ Z alkene isomerization is intimately entwined in the historical fabric of
organic photochemistry and is enjoying a renaissance (Roth et al. Angew. Chem., Int. Ed …

Many biological processes are executed and regulated through the molecular interactions of
proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the …

As the breadth of radical chemistry grows, new means to promote and regulate single-
electron redox activities play increasingly important roles in driving modern synthetic …

The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …