A global review on short peptides: frontiers and perspectives
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …
entities via all domains of life and interfere with protein-protein interactions, which are …
Cysteine protecting groups: applications in peptide and protein science
RJ Spears, C McMahon, V Chudasama - Chemical Society Reviews, 2021 - pubs.rsc.org
Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …
'Smart'insulin-delivery technologies and intrinsic glucose-responsive insulin analogues
Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood
glucose concentration above or below the therapeutic range (hyper-or hypoglycaemia). To …
glucose concentration above or below the therapeutic range (hyper-or hypoglycaemia). To …
The chemical synthesis of insulin: an enduring challenge
The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …
Ready to Use Cysteine Thiol Protecting Groups in SPPS, A Practical Overview
A Chakraborty, SN Mthembu… - … Process Research & …, 2024 - ACS Publications
Protecting group chemistry plays a pivotal role during peptide synthesis. For the synthesis of
cysteinyl peptides, this is more significant as cysteine (Cys) is involved in the formation of …
cysteinyl peptides, this is more significant as cysteine (Cys) is involved in the formation of …
Stepwise construction of disulfides in peptides
The disulfide bond plays an important role in biological systems. It defines global
conformation, and ultimately the biological activity and stability of the peptide or protein. It is …
conformation, and ultimately the biological activity and stability of the peptide or protein. It is …
Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers
μ-Conotoxins are components of cone snail venom, well-known for their analgesic activity
through potent inhibition of voltage-gated sodium channel (Na V) subtypes, including Na V …
through potent inhibition of voltage-gated sodium channel (Na V) subtypes, including Na V …
Palladium‐Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐cysteine under Aqueous Conditions
One of the applied synthetic strategies for correct disulfide bond formation relies on the use
of orthogonal Cys protecting groups. This approach requires purification before and after the …
of orthogonal Cys protecting groups. This approach requires purification before and after the …
Strategies for interference of insulin fibrillogenesis: challenges and advances
The discovery of insulin came with very high hopes for diabetic patients. In 2021, the world
celebrated the 100th anniversary of the discovery of this vital hormone. However, external …
celebrated the 100th anniversary of the discovery of this vital hormone. However, external …
Novel four-disulfide insulin analog with high aggregation stability and potency
X Xiong, A Blakely, P Karra, MA VandenBerg… - Chemical …, 2020 - pubs.rsc.org
Although insulin was first purified and used therapeutically almost a century ago, there is still
a need to improve therapeutic efficacy and patient convenience. A key challenge is the …
a need to improve therapeutic efficacy and patient convenience. A key challenge is the …