Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy

MA Peltoniemi, NM Hagelberg, KT Olkkola… - Clinical …, 2016 - Springer
Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-
methyl-d-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the …

Ketamine use in current clinical practice

M Gao, D Rejaei, H Liu - Acta Pharmacologica Sinica, 2016 - nature.com
After nearly half a century on the market, ketamine still occupies a unique corner in the
medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two …

The pain management of trauma patients in the emergency department

A Fabbri, A Voza, A Riccardi, S Serra… - Journal of Clinical …, 2023 - mdpi.com
The vast majority of injured patients suffer from pain. Systematic assessment of pain on
admission to the emergency department (ED) is a cornerstone of translating the best …

Intravenous subdissociative-dose ketamine versus morphine for analgesia in the emergency department: a randomized controlled trial

S Motov, B Rockoff, V Cohen, I Pushkar… - Annals of emergency …, 2015 - Elsevier
Study objective We assess and compare the analgesic efficacy and safety of subdissociative
intravenous-dose ketamine with morphine in emergency department (ED) patients. Methods …

Low‐dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double‐blind …

FL Beaudoin, C Lin, W Guan… - Academic Emergency …, 2014 - Wiley Online Library
Objectives Low‐dose ketamine has been used perioperatively for pain control and may be a
useful adjunct to intravenous (IV) opioids in the control of acute pain in the emergency …

Ketamine: use in anesthesia

S Marland, J Ellerton, G Andolfatto… - CNS neuroscience & …, 2013 - Wiley Online Library
The role of ketamine anesthesia in the prehospital, emergency department and operating
theater settings is not well defined. A nonsystematic review of ketamine was performed by …

Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial

JP Miller, SG Schauer, VJ Ganem… - The American journal of …, 2015 - Elsevier
Objectives To compare the maximum change in numeric rating scale (NRS) pain scores, in
patients receiving low-dose ketamine (LDK) or morphine (MOR) for acute pain in the …

Comparative effectiveness of analgesics to reduce acute pain in the prehospital setting

DM Sobieraj, BK Martinez, B Miao… - Prehospital …, 2020 - Taylor & Francis
Objectives: The objectives of this study were to assess comparative effectiveness and harms
of opioid and nonopioid analgesics for the treatment of moderate to severe acute pain in the …

A review of current and emerging approaches to pain management in the emergency department

KH Todd - Pain and therapy, 2017 - Springer
Introduction Pain is the most common symptom prompting an emergency department visit
and emergency physicians are responsible for managing both acute pain and acute …

[PDF][PDF] A triple-option analgesia plan for tactical combat casualty care: TCCC guidelines change 13-04

FK Butler, RS Kotwal, CC Buckenmaier… - J Spec Oper …, 2014 - researchgate.net
Although the majority of potentially preventable fatalities among US combat forces serving in
Afghanistan and Iraq have died from hemorrhagic shock, the majority of US medics carry …