Gestational trophoblastic disease describes a group of rare pregnancy related disorders that
span a spectrum of premalignant and malignant conditions. Hydatidiform mole (also termed …

Choriocarcinoma is a malignant tumor caused by aberrant proliferation and excessive
invasion of trophoblastic cells in the uterus. Treatment for choriocarcinoma is hampered by …

Background: Today, most women with gestational trophoblastic disease (GTD) can expect to
be cured, particularly if they live in middle-to high-income countries with access to GTD …

Breast cancer is the most common tumor in women, and selective cyclin-dependent kinase
(CDK) 4/6 inhibitors played an important role in the treatment of breast cancer. Therefore …

Enhanced drug efflux through ATP-binding cassette transporters, particularly P-glycoprotein
(P-gp), is a key mechanism underlying multidrug resistance (MDR). In the present study, we …

Background Oncogenic multidrug resistance (MDR) is a tough question in cancer therapy.
However, no effective medications targeting oncogenic MDR are currently available. Studies …

Osteosarcoma (OS) is a primary bone cancer mostly found in adolescents and elderly
individuals. The treatment of OS is still largely dependent on traditional chemotherapy …

Objective The treatment for high risk or recurrent gestational trophoblastic neoplasia (GTN)
is a highly toxic multi-agent chemotherapy. For patients with progressive or recurrent GTN …

KRAS is commonly mutated in solid tumours but effective treatment is limited due to
resistance. Cancer-associated fibroblasts (CAFs) are a key tumour microenvironment …