Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer
progression, metastasis and drug resistance. Although there are controversies surrounding …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …

Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …

Our understanding of epithelial-to-mesenchymal transition (EMT) has slowly evolved from a
simple two state, binary model to a multi-step, dynamic continuum of epithelial-to …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …