The function and regulation of zinc in the brain
RF Krall, T Tzounopoulos, E Aizenman - Neuroscience, 2021 - Elsevier
Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …
Neuronal signalling of zinc: From detection and modulation to function
Zinc is an essential trace element that stabilizes protein structures and allosterically
modulates a plethora of enzymes, ion channels and neurotransmitter receptors. Labile zinc …
modulates a plethora of enzymes, ion channels and neurotransmitter receptors. Labile zinc …
MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx
J Qi, Y Xing, Y Liu, MM Wang, X Wei, Z Sui, L Ding… - Autophagy, 2021 - Taylor & Francis
Macroautophagy/autophagy is elevated to ensure the high demand for nutrients for the
growth of cancer cells. Here we demonstrated that MCOLN1/TRPML1 is a pharmaceutical …
growth of cancer cells. Here we demonstrated that MCOLN1/TRPML1 is a pharmaceutical …
A new hemostatic agent composed of Zn2+-enriched Ca2+ alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo
AC Ponsen, R Proust, S Soave, F Mercier-Nomé… - Bioactive Materials, 2022 - Elsevier
To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as
Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a …
Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a …
The contribution of zinc to platelet behaviour during haemostasis and thrombosis
Platelets are the primary cellular determinants of haemostasis and pathological thrombus
formation leading to myocardial infarction and stroke. Following vascular injury or …
formation leading to myocardial infarction and stroke. Following vascular injury or …
Heavy metal cations permeate the TRPV6 epithelial cation channel
G Kovacs, T Danko, MJ Bergeron, B Balazs, Y Suzuki… - Cell calcium, 2011 - Elsevier
TRPV6 belongs to the vanilloid family of the transient receptor potential channel (TRP)
superfamily. This calcium-selective channel is highly expressed in the duodenum and the …
superfamily. This calcium-selective channel is highly expressed in the duodenum and the …
Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin …
C Richards-Williams, JL Contreras, KH Berecek… - Purinergic …, 2008 - Springer
It is well established that ATP is co-secreted with insulin and zinc from pancreatic beta-cells
(β-cells) in response to elevations in extracellular glucose concentration. Despite this …
(β-cells) in response to elevations in extracellular glucose concentration. Despite this …
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals
MB Hovater, D Olteanu, EL Hanson, NL Cheng… - Purinergic …, 2008 - Springer
Renal epithelial cells release ATP constitutively under basal conditions and release higher
quantities of purine nucleotide in response to stimuli. ATP filtered at the glomerulus …
quantities of purine nucleotide in response to stimuli. ATP filtered at the glomerulus …
P2X purinergic receptors are multisensory detectors for micro-environmental stimuli that control migration of tumoral endothelium
Simple Summary Extracellular ATP is highly concentrated in tumor stroma. In this study, we
investigated the effects of the synthetic ATP analog Benzoylbenzoyl-ATP, 2′(3′)-O-(4 …
investigated the effects of the synthetic ATP analog Benzoylbenzoyl-ATP, 2′(3′)-O-(4 …
Autophagy-induced degradation of Notch1, achieved through intermittent fasting, may promote beta cell neogenesis: implications for reversal of type 2 diabetes
JJ DiNicolantonio, M McCarty - Open Heart, 2019 - openheart.bmj.com
INTERMITTENT FASTING BOOSTS NEUROGENIN-3 (NGN3) EXPRESSION AND BETA
CELL NEOGENESIS Several recent studies have found that repeated episodes of fasting (or …
CELL NEOGENESIS Several recent studies have found that repeated episodes of fasting (or …