Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

The evolution of regenerative capacity in multicellular animals represents one of the most
complex and intriguing problems in biology. How could such a seemingly advantageous trait …

Growing evidence supports the antagonistic pleiotropy theory of mammalian aging.
Accordingly, changes in gene expression following the pluripotency transition, and …

Microplastics pose risks to marine organisms through ingestion, entanglement, and as
carriers of toxic additives and environmental pollutants. Plastic pre-production pellet …

The peripheral nerves (PNs) innervate the dermis and epidermis, and are suggested to play
an important role in wound healing. Several methods to quantify skin innervation during …

Simple Summary Diabetes is a chronic metabolic disease characterized by high blood
glucose levels (hyperglycemia). Type 2 diabetes mellitus (T2DM) and its complications are a …

As the only known mammalian organ that can fully and annually regenerate, deer antler has
significant advantages over lower-order animal models when investigating the control of …

Regeneration relies on cell proliferation to restore damaged tissues. Multiple signaling
pathways activated by local or paracrine cues have been identified to promote regenerative …

During development, regulation of organ size requires a balance between cell proliferation,
growth and cell death. Dysregulation of these fundamental processes can cause a variety of …

The regenerative capacity of cnidarians plays an essential role in the maintenance and
restoration of coral reef ecosystems by allowing faster recovery from disturbances and more …