The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Here, we aimed to chemically modify PAMAM dendrimers using lysine as a site-selective
anchor for successfully delivering mRNA while maintaining a low toxicity profile. PAMAM …

Hydrogels are of growing interest for the delivery of therapeutics to specific sites in the body.
For use as a delivery vehicle, hydrophilic precursors are usually laden with bioactive …

Nanotheranostics is a relatively new, fast-growing field that combines the advantages of
treatment and diagnosis via a single nanoscale carrier. The ability to bundle both …

RNA interference by small interfering RNA (siRNA) holds promise to attenuate production of
specific target proteins but is challenging in practice owing to the barriers for its efficient …

Biomaterials and Bionanotechnology examines the current state of the field within
pharmaceutical sciences and concisely explains the history of biomaterials including key …

Nanoparticle-mediated siRNA delivery is a complex process that requires transport across
numerous extracellular and intracellular barriers. As such, the development of nanoparticles …