Introduction Synovitis–acne–pustulosis–hyperostosis–osteitis (SAPHO) is an acronym for
various osteoarticular and dermatological manifestations that can appear in the same …

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is an umbrella acronym for
inflammatory clinical conditions whose common denominator is aseptic osteoarticular …

SAPHO and recurrent multifocal osteomyelitis are complex inflammatory conditions whose
features center on a variety of osteoarticular and cutaneous manifestations (Fig. 1). The …

Long‐term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical
course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been …

Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease characterized by
sterile pustules on the palms and soles. Pustulotic arthro‐osteitis (PAO) is a major …

Background and objectives Synovitis acne pustulosis hyperostosis osteitis (SAPHO) is a
rare heterogeneous disease of unknown aetiopathology. Externally validated and …

Autoinflammation is characterized by aberrant regulation of the innate immune system and
often manifests as periodic fevers and systemic inflammation involving multiple organs …

SAPHO syndrome (SS) is an autoinflammatory disease characterized by synovitis, acne,
pustulosis, hyperostosis, and osteitis. Among the sites affected by the osteoarticular …

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition thought to be under-
diagnosed, with a true prevalence of more than the 1 in 10,000 estimated. It is a condition …

Palmoplantar pustulosis (PPP) is a chronic inflammatory disease, most often occurring in
middle-aged women. In the course of the condition, painful skin lesions appear on the hands …