Autophagy is a process of degradation of macromolecules in the cytoplasm, particularly
proteins of a long half-life, as well as whole organelles, in eukaryotic cells. Lysosomes play …

The PMCA (protein misfolding cyclic amplification) technique has been shown to drive the
amplification of misfolded prion protein by PrPSc seeds during several cycles of incubation …

In 1987 I had the pleasant task of reviewing the precursor of this book, which was called
Viral Encephalitis: Pathology, Diagnosis and Management. The strongly positive tone of that …

The conversion of cellular prion protein (PrPC) to the protease resistant isoform (PrPSc) is
considered essential for the progression of transmissible spongiform encephalopathies …

Among the ever-growing number of self-replicating proteins involved in neurodegenerative
diseases, the prion protein PrP remains the most infamous for its central role in transmissible …

Prion diseases are rare, rapidly progressive, fatal neurodegenerative illnesses caused by an
abnormal isoform of the native prion protein. Creutzfeldt-Jakob disease (CJD) is the most …

Sodium valproate (VPA) has been reported to increase the accumulation of the pathologic
isoform of prion protein (PrP sc) in scrapie-infected murine neuroblastoma cells. In this …

Jakob–Creutzfeldt disease (JCD) is a rare prion-mediated disease that causes rapidly
progressive dementia. Prions are pathogenic, misfolded proteins that propagate via an …

Η σύγχρονη ιατρική έχει να παρουσιάσει πολλά επιτεύγματα, που οδήγησαν στη βελτίωση της
ποιότητας της ζωής των ανθρώπων. Η παρασκευή φαρμακευτικών ουσιών που …

Les maladies à prions ou encéphalopathies spongiformes subaiguës transmissibles sont
des maladies anciennes qui connaissent un regain de notoriété depuis 1996, avec la crise …