Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for
embryonic development, wound healing, and cancer metastasis. However, how Ca2+ …

Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

The metabolite acetyl-coenzyme A (acetyl-CoA) is the required acetyl donor for lysine
acetylation and thereby links metabolism, signaling, and epigenetics. Nutrient availability …